195 Female sex and mortality in SAB 9 Ethical approval Ethical approval was granted by the Duke University Medical Center institutional review board. Results A total of 3384 patients were enrolled from 1994 to 2020. Among them, 1431 (42%) were women. Median age was 60 years in both sexes (Fig. S2). Female patients with SAB were, as compared with male patients, more frequently Black (581/1431 [41%] vs. 620/ 1953 [32%], p < 0.001), more often haemodialysis dependent (309/ 1424 [22%] vs. 334/1940 [17%], p 0.001), more likely to have implanted foreign material (817/1422 [58%] vs. 1014/1949 [52%], p 0.002) and more likely to have used corticosteroids in the past month (315/1422 [22%] vs. 355/1933 [18%], p 0.008, Table 1). By contrast, men more frequently had a history of injection drug use (142/1933 [7%] vs. 64/1422 [5%], p 0.001) and experienced higher rates of metastatic infection (813/1952 [42%] vs. 512/1431 [36%], p 0.001). Microbiological characteristics Women were more likely to be infected with MRSA as opposed to MSSA, compared with males (697/1410 [49%] MRSA in female patients vs. 840/1925 [44%] MRSA in male patients, p 0.001). In the 3136 isolates that were genotyped, 516 distinct spa types were identified, which were equally distributed between the sexes (p 0.265, Table S1). Ninety-one per cent (2599/2843) of the isolates with an identified Clonal Complex (CC) belonged to one of the six most common CCs: CC002, CC004, CC008, CC012, CC084, and CC0189, which were also similarly distributed between sexes (p 0.080, Table S2). The percentage of patients infected with the USA300 clone was equal in women and men (respectively 130/1326 and 173/1810, both 10%, p 0.854, Table 1).
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