182 Chapter 8 72. Schweizer, M.L.; Furuno, J.P.; Sakoulas, G.; Johnson, J.K.; Harris, A.D.; Shardell, M.D.; McGregor, J.C.; Thom, K.A.; Perencevich, E.N. Increased Mortality with Accessory Gene Regulator (agr) Dysfunction in Staphylococcus aureus among Bacteremic Patients. Antimicrob. Agents Chemother. 2011, 55, 1082–1087. 73. Jang, H.-C.; Kang, S.-J.; Choi, S.-M.; Park, K.-H.; Shin, J.-H.; Choy, H.E.; Jung, S.-I.; BIN Kim, H. Difference in agr Dysfunction and Reduced Vancomycin Susceptibility between MRSA Bacteremia Involving SCCmec Types IV/IVa and I–III. PLoS ONE 2012, 7, e49136. 74. Park, S.-Y.; Chong, Y.P.; Park, H.J.; Park, K.-H.; Moon, S.M.; Jeong, J.-Y.; Kim, M.-N.; Kim, S.-H.; Lee, S.-O.; Choi, S.-H.; et al. agr dysfunction and persistent methicillin-resistant Staphylococcus aureus bacteremia in patients with removed eradicable foci. Infection 2012, 41, 111–119. 75. Kang, C.K.; Kim, Y.K.; Jung, S.I.; Park, W.B.; Song, K.H.; Park, K.H.; Choe, P.G.; Jang, H.C.; Lee, S.; Kim, Y.S.; et al. agr functionality affects clinical outcomes in patients with persistent methicillin-resistant Staphylococcus aureus bacteraemia. Eur. J. Clin. Microbiol. Infect. Dis. 2017, 36, 2187–2191. 76. Xiong, Y.Q.; Fowler, J.V.G.; Yeaman, M.R.; Perdreau-Remington, F.; Kreiswirth, B.N.; Bayer, A.S. Phenotypic and Genotypic Characteristics of Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia In Vitro and in an Experimental Endocarditis Model. J. Infect. Dis. 2009, 199, 201–208. 77. Seidl, K.; Bayer, A.S.; Fowler, V.G., Jr.; McKinnell, J.A.; Abdel Hady, W.; Sakoulas, G.; Yeaman, M.R.; Xiong, Y.Q. Combinatorial Phenotypic Signatures Distinguish Persistent from Resolving Methicillin-Resistant Staphylococcus aureus Bacteremia Isolates. Antimicrob. Agents Chemother. 2011, 55, 575–582. 78. Yeaman, M.R. Platelets in defense against bacterial pathogens. Cell. Mol. Life Sci. 2009, 67, 525–544. 79. Dhawan, V.K.; Yeaman, M.R.; Bayer, A.S. Influence of In Vitro Susceptibility Phenotype against Thrombin?Induced Platelet Microbicidal Protein on Treatment and Prophylaxis Outcomes of Experimental Staphylococcus aureus Endocarditis. J. Infect. Dis. 1999, 180, 1561–1568. 80. Brauner, A.; Fridman, O.; Gefen, O.; Balaban, N.Q. Distinguishing between resistance, tolerance and persistence to antibiotic treatment. Nat. Rev. Microbiol. 2016, 14, 320–330. 81. Surewaard, B.G.; Deniset, J.F.; Zemp, F.J.; Amrein, M.; Otto, M.; Conly, J.; Omri, A.; Yates, R.M.; Kubes, P. Identification and treatment of the Staphylococcus aureus reservoir in vivo. J. Exp. Med. 2016, 213, 1141–1151. 82. Lehar, S.M.; Pillow, T.; Xu, M.; Staben, L.; Kajihara, K.K.; Vandlen, R.; DePalatis, L.; Raab, H.; Hazenbos, W.L.; Morisaki, J.H.; et al. Novel antibody–antibiotic conjugate eliminates intracellular S. aureus. Nature 2015, 527, 323–328. 83. Rowe, S.E.; Wagner, N.J.; Li, L.; Beam, J.E.; Wilkinson, A.D.; Radlinski, L.C.; Zhang, Q.; Miao, E.A.; Conlon, B.P. Reactive oxygen species induce antibiotic tolerance during systemic Staphylococcus aureus infection. Nat. Microbiol. 2019, 5, 282–290. 84. Beam, J.E.; Rowe, S.E.; Conlon, B.P. Shooting yourself in the foot: How immune cells induce antibiotic tolerance in microbial pathogens. PLoS Pathog. 2021, 17, e1009660. 85. Ledger, E.V.K.; Mesnage, S.; Edwards, A.M. Human serum triggers antibiotic tolerance in Staphylococcus aureus. Nat. Commun.2022, 13, 2041. 86. Huemer, M.; Shambat, S.M.; Brugger, S.D.; Zinkernagel, A.S. Antibiotic resistance and persistence—Implications for human health and treatment perspectives. EMBO Rep. 2020, 21, e51034.
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