151 Acute kidney injury in SAB 7 Legend: a Cox regression of all patients with acute kidney injury. Recovery of kidney function was defined as return of creatinine < 1.5 × baseline creatinine. Both: Uncomplicated SAB was defined as an episode of bacteraemia with ≥ 1 blood culture with Staphylococcus aureus, without evidence of endocarditis/metastatic infection, and without positive cultures after 48 h of adequate therapy and that was treated for a maximum of 2 weeks, and no relapse occurred, and the patient survived > 72 h after presentation. All situations that did not meet the criteria for uncomplicated SAB were considered complicated SAB Table 3. Factors associated with development of AKI in SAB Variable OR (95%CI) p-value B OR (95%CI) p-value Patient characteristics Age >60y 1.91 (1.1-3.2) 0.01 0.29 1.33 (0.67-2.63) 0.41 Male sex 0.69 (0.4-1.1) 0.13 -0.50 0.61 (0.33-1.12) 0.11 Complicated SAB 2.73 (1.7-4.5) <0.01 1.23 3.42 (1.84-6.36) <0.01 Medical history Chronic kidney disease 2.19 (1.3-3.6) <0.01 0.39 1.06 (0.49-2.30) 0.24 Diabetes 1.45 (0.9-2.4) 0.23 Cardiovascular disease 2.31 (1.4-3.7) <0.01 0.06 1.06 (0.49-2.30) 0.87 Malignancy 0.97 (0.6-1.7) 1.00 Medication Use of ACE-i/ARB 1.89 (1.2-3.1) 0.02 -0.31 0.73 (0.35-1.54) 0.41 Use of diuretic agent 3.07 (1.9-5.0) <0.01 0.70 2.01 (0.99-4.06) 0.05 Clinical and laboratory parameters at presentation Hemodynamic instability 6.20 (2.8-13.8) <0.01 1.97 7.17 (2.51-20.48) <0.01 Temperature > 38.5˚C 0.59 (0.4-0.9) 0.03 -0.28 0.76 (0.42-1.37) 0.36 Leukocyte count > 15 x10⁹/L 1.54 (0.9-2.5) 0.08 0.32 1.37 (0.73-2.57) 0.32 CRP > 150mg/L 1.63 (1.0-2.6) 0.04 0.26 1.30 (0.70-2.39) 0.41 Legend: Univariate and multivariable analysis of risk factors for acute kidney injury in patients with S. aureus bacteremia. OR odds ratio, B regression coefficients. Chronic kidney disease was defined as an eGFR < 60 ml/min/1,73 m2. Cardiovascular disease consists of hypertension, vascular disease, and/ or heart failure. Hemodynamic instability was defined as a mean arterial pressure (MAP) < 65 mmHg or systolic blood pressure < 90 mmHg or need of inotropic or vasopressor agents. ACE-i angiotensinconvertingenzyme inhibitors, ARB angiotensin II receptor blockers, CRP C-reactive protein.
RkJQdWJsaXNoZXIy MTk4NDMw