149 Acute kidney injury in SAB 7 Risk factors for AKI In the univariate analyses, age > 60 years, complicated SAB, chronic kidney disease, cardiovascular disease, the use of diuretics or ACE-i/ARB, hemodynamic instability, temperature > 38.5˚C, and CRP > 150 mg/L, all at baseline, were associated with development of AKI (Table 3). In the multivariable logistic regression analysis, independent riskfactors for AKI were complicated SAB, use of diuretics and hemodynamic instability (Table 3). Table 2. Gradations of acute kidney injuries Total incidenceᵅ Recovery of AKIᵇ Maximum creatinine 1.5x - 2.5x baseline 74 (64) 51 (68) 2.5x - 3.5x baseline 17 (15) 10 (59) > 3.5x baseline 8 (7) 2 (25) Renal replacement therapy 16 (14) 6 (38) Legend: Total of 115 patients with acute kidney injury (AKI) divided in categories of severity of renal impairment. Values are count (%). ɑPercentages are of column (total group of patients with AKI). bPercentages are of row (group of patients in this category of AKI). Recovery of AKI was defined as creatinine drop below 1.5 times baseline creatinine again. Renal replacement therapy was either continuous venovenous hemofiltration (CVVH) or dialysis. Subgroup analyses In the subgroup of patients presenting with hemodynamic instability (n = 35), 26/35 (74%) developed AKI. In 12/26 (46%) patients, AKI was reversible. In the subgroup of patients with chronic kidney insufficiency (n = 53), 31/53 (59%) developed AKI. In 16/31 (52%), AKI was reversible.
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