145 Acute kidney injury in SAB 7 between complicated and uncomplicated SAB. Additional knowledge of AKI in SAB may provide clinicians tools to predict risk of AKI in individual patients and support diagnostic and therapeutic management. Eventually, it could lead to initiation of intervention studies aimed at prevention or treatment of AKI in patients with SAB. Methods Study population This multicenter retrospective cohort study was performed in one academic and two large teaching hospitals in the Netherlands. Patients that were diagnosed with SAB in the period January 2013 to December 2017 were eligible for inclusion. Data on this study cohort have been published previously [7]. All consecutive adult patients (≥ 18 years) with ≥ 1 blood culture positive for S. aureus were eligible for inclusion. Patients were excluded if (a) S. aureus was detected simultaneously with other pathogens (polymicrobial culture), (b) patients were already on renal dialysis before admission, (c) and AKI occurred prior to the episode of SAB. In patients with multiple episodes of SAB, only the first episode was included. Both patients with community acquired SAB and patients who developed SAB during hospitalization for another indication (hospital acquired SAB) were eligible for inclusion. Data collection Blood samples were inoculated in both anaerobic and aerobic bottles and incubated in the BACTEC FX continuous monitoring system (Becton Dickinson BV, Breda, The Netherlands). The clinical data were obtained through review of the electronic patient files. The following data were collected: demographic data, medical history, chronic medication, antibiotic therapy administered for treatment of the SAB episode, vital parameters, and the presence of complicated versus uncomplicated SAB. Baseline serum creatinine (μmol/L), i.e., the most recent known serum creatinine before the presentation with SAB, creatinine at presentation, and maximum creatinine during admission were retrieved from the electronic laboratory system. Furthermore, the time to maximum serum creatinine and the time from maximum creatine to recovery of creatinine were retrieved. Definitions Acute kidney injury was defined as 1.5 times baseline creatinine. Recovery of kidney function was defined as creatinine returning to below 1.5 times baseline creatinine during follow-up. The absence of recovery of renal function < 1.5 times baseline creatinine during follow-up was considered non-reversible AKI. Hemodynamic
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