131 Global differences in SAB management 6 Do you consider first-generation cephalosporins (e.g. cefazoline) to have equivalent clinical effectiveness for MSSA bacteremia without central nervous system infection as antistaphylococcal penicillins ( e.g. flucloxacillin, dicloxacillin)? o Yes o No Do you treat patients with Staphylococcus aureus bacteremia and the following types of infected prosthetic material which will not be removed with rifampicin as part of combination antibiotic therapy provided the isolate is susceptible to the drug? Mark all that apply. □ Cardiac device □ Endovascular graft □ Joint prosthesis □ Prosthetic heart valve □ Spondylodesis □ All of the above □ None of the above The following question refers to MRSA bacteremia What is your first-choice initial antibiotic regimen in patients with confirmed monobacterial MRSA bacteremia without implanted prosthetic material provided the isolate is susceptible to the drug? □ Aminoglycoside, e.g. gentamicin □ Clindamycin □ Fifth generation cephalosporin, i.e. ceftaroline □ Fluoroquinolone, e.g. levofloxacin □ Fosfomycin □ Glycopeptide, e.g. vancomycin □ Linezolid □ Lipopeptide, e.g. daptomycin □ Rifampicin □ Tetracycline, e.g. doxycycline □ Trimethoprim/sulfamethoxazole □ Other □ Combination therapy The following questions refer to persistent bacteremia. After how many days (-or more) of positive blood cultures with S. aureus despite adequate antibiotic therapy would you consider it a ‘persistent bacteremia’? o 2 days o 3 days o 4 days o 5 days o 6 days o 7 days o >7 days o Do not know
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