I 187

1 Introduction 13
1.1 Background 14
1.2 Optimization through digital simulations 17
2 Real-world indoor mobility with simulated prosthetic vision 21
2.1 Introduction 22
2.2 Materials and methods 23
2.3 Results 28
2.4 Discussion 31
2.5 Conclusion 35
3 Towards a task-based computational evaluation benchmark 37
3.1 Introduction 38
3.2 Methods 39
3.3 Results 45
3.4 Discussion 47
4 End-to-end optimization of prosthetic vision 51
4.1 Introduction 52
4.2 Methods 53
4.3 Experiments and Results 55
4.4 Discussion 63
4.5 Conclusion 66
5 Towards biologically plausible phosphene simulation 69
5.1 Introduction 70
5.2 Materials and methods 74
5.3 Results 78
5.4 Discussion 84
5.5 Conclusion 91
6 Gaze-contingent processing improves mobility performance 103
6.1 Introduction 104
6.2 Materials and Methods 106
6.3 Results 114
6.4 Discussion 117
6.5 Conclusion 120
7 Summary 123
8 General discussion 127
8.1 Naturalistic prototyping of hardware & software 127
8.2 Automated optimization with virtual implant users 129
8.3 The biology of visual neurostimulation 130
8.4 Further considerations 131
8.5 Limitations and future directions 133
8.6 Conclusion 133
Bibliography 137
Code and Data 163
Acknowledgements 167
Nederlandse Samenvatting 171

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