80 | wetenschapsdag 2023 Sessie 2d: Laparos: het Ontwerp Binnenste Binnen Keren x4 Auteurs M. Abu Hilal, B.A. Uijterwijk, D.H.L Lemmers, B.V. Janssen, M.G. Besselink, B. Groot Koerkamp, A. Fariña, J. Verheij, H. Wilmink, H. Asbun, V. Adsay, C. Verbeke Abstract titel International multidisciplinary consensus guidelines on the optimal pathology assessment and multidisciplinary pathways of non-pancreatic neoplasms in and around the ampulla of Vater (PERIPAN) Background The absence of multidisciplinary workflow guidelines and clear definitions and classifications for non-pancreatic neoplasms in and around the ampulla of Vater, including distal cholangiocarcinoma, duodenal carcinoma, and the (intestinal/pancreatobiliary/mixed/ hybrid) subtypes of ampullary cancer, results in inconsistencies in research and impacts patient care. These international multidisciplinary consensus guidelines aimed to standardize the multidisciplinary diagnostic workflow and to achieve consensus on uniform definitions and classifications in order to improve patient care and unify future research. Methods The consensus questions consisted of two parts, the multidisciplinary team (MDT) guidelines and the pathology guidelines. The Scottish Intercollegiate Guidelines Network methodology (SIGN), including the Delphi methodology, to achieve consensus and the AGREEII tool for quality assessment and external validation were used to create evidence-based consensus guidelines. 45 experts (pathologists, oncologists, surgeons, gastroenterologists, radiologists) from 12 countries were invited based on their expertise in this topic. Results In total, 37.061 articles were screened of which 229 were included for final literature assessment. Based on the latter and the expert teams’ expertise, 39 consensus questions with 57 recommendations were created for eight multidisciplinary pathway and eight pathology topics, through three Delphi rounds. The PERIPAN consensus guidelines were presented and externally validated in an open access conference.
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