56 | wetenschapsdag 2023 Sessie 2a: Den Nederlanden - en Daar Voorbij x1 Auteurs H. Groenen, H. Jalalzadeh, R.R. Bahethi, A.A.A. Bediako-Bowan, K. M’lbak, M.A. Bohl, N.M.C. Mathijssen, G. Hannink, B.L. Hollenbeck, F.J. Prakken, N. Wolfhagenå, M.A. Boermeester Abstract titel The effect of door openings in the operating room on the incidence of surgical site infections: an individual patient data meta-analysis Background The influence of door openings in the operating room on the occurrence of surgical site infections (SSI) has been a controversial topic for several years. Many care bundles on the prevention of SSI include limitation of traffic flow, including door openings, as element. However, evidence is limited and heterogeneous. Therefore, the purpose of this individual patient data (IPD) meta-analysis is to evaluate the effect of the number of door openings during surgery in the operating room on the occurrence of SSI. Methods We searched PubMed, Embase and Cochrane CENTRAL databases inception to January 26, 2023 for prospective, retrospective, or randomised trials investigating the effect of door openings in the operating room on the incidence of SSI. Authors of eligible studies were invited for collaboration. Individual patient data were merged after validation. Descriptive analyses and onestage IPD meta-analyses using generalized mixed linear modelling were conducted. This study is registered with PROSPERO, CRD42022309958. Results Individual patient data of 1747 patients from seven observational studies were analysed. We found an overall SSI incidence of 9.3%. The incidence of SSI was not significantly increased by additional door openings in the operating room. Conclusion In this individual participant data meta-analysis we found no evidence of a relation between the number of door openings in the operating room and the occurence of SSI.
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