wetenschapsdag 2023 | 53 Sessie 1d: Een Goede Fundering Voor de Chirurgische Lering 6 Auteurs E. Aalbregt, L. Rijken, A.J. Nederveen, P. van Ooij, K. Yeung, V. Jongkind Abstract titel Quantitative Magnetic Resonance Imaging to Assess Progression and Rupture Risk of Aortic Aneurysms: a Scoping Review Background In current practice, the diameter of an aortic aneurysm is utilised to estimate the rupture risk and decide upon timing of elective repair, although it is known to be imprecise and not patientspecific. Quantitative magnetic resonance imaging (MRI) enables the visualisation of several biomarkers that provide information about processes within the aneurysm and may therefore facilitate patient-specific risk stratification. We performed a scoping review of the literature on quantitative MRI techniques to assess aortic aneurysm progression and rupture risk, summarised these findings, and identified knowledge gaps. Methods Literature concerning primary research was of interest and the medical databases PubMed, Scopus, Embase and Cochrane were systematically searched. This study used the PRISMA protocol extension for scoping reviews. Articles published between January 2010 and February 2023 involving animals and/or humans were included. Data were extracted by two authors using a predefined charting method. Results A total of 1641 articles were identified, of which 21 were included in the scoping review. Quantitative MRI-derived biomarkers were categorised into haemodynamic (eight studies), wall (five studies) and molecular biomarkers (eight studies). Fifteen studies included patients and/or healthy human subjects. Animal models were investigated in the other six studies. A cross-sectional study design was the most common, whereas five animal studies had a longitudinal component and two studies including patients had a prospective design. A promising haemodynamic biomarker is wall shear stress (WSS), which is estimated based on 4D flow MRI. Molecular biomarkers enable the assessment of inflammatory and wall deterioration processes. The ADAMTS4-specific molecular MR probe showed potential to predict abdominal aortic aneurysm (AAA) formation and rupture in a murine model. Wall biomarkers assessed using dynamic contrast-enhanced (DCE) MRI showed great potential for assessing AAA progression independent of the maximum diameter.
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