wetenschapsdag 2023 | 19 Openingssessie x Auteurs D.J. van de Berg Title Fluorescence Imaging for the Perfusion of the Parathyroid Glands of Children (FLUOPATCH) Background Postoperative hypocalcemia, a severe complication of pediatric thyroid surgery, occurs in 20-67% of the children and leads to a lifelong reduced quality of life and increased morbidity rates. In adults, quantified ICG-fluorescence angiography of the parathyroid glands has shown to reduce postoperative hypocalcemia. However, in children no studies have yet been conducted. The aim of this study is to develop a standardized imaging workflow model for quantified ICG-angiography of the parathyroid glands in children. Methods Study design: A prospective, observational, multicenter, feasibility study. Population: Patients (<18 years of age) undergoing total thyroidectomy for any indication. Duration and participating centers: Participant enrollment will occur over a twelve month period in Amsterdam UMC, UMC Utrecht and UMC Groningen. Intervention: Patients will always receive standard care. For the purpose of this study, the camera set-up (i.e. camera distance to the operating field) and ICG-protocol (i.e. dose, injection speed) will be standardized among the participating centers in order to generate an homogeneous data set for quantification of the fluorescence signal intensity. Primary objective: Primary goal of this study is to create a standardized and user-independent workflow model of quantified ICG-angiography of the parathyroid glands in children. This workflow model can be the first step in reducing the rate of postoperative hypocalcemia in children. 3
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