wetenschapsdag 2023 | 101 Sessie 3c: Zing, Vecht, Huil, Bid, Lach, Werk en Bewonder x5 Auteurs B.L. Tran; N.J.S. Thiermann, V. Jongkind, R. Balm, J.H. Nederhoed, A.J.W. Hoksbergen, M.J.W. Koelemaij, J.D. Blankensteijn; K.K. Yeung Abstract titel The Pearl-AAA Biobank to better understand AAA progression and risk for rupture Background An abdominal aortic aneurysm (AAA) is a permanent dilatation of the abdominal aorta that poses a life-threatening condition if rupture occurs. The current approach in assessing AAA patients based on comorbidity, clinical risk factors, and aortic diameter is insufficient for understanding disease progression. Therefore, the Pearl-AAA/PARIS study was initiated to observe the natural course of AAA development. Methods The Pearl-AAA biobank is an ongoing multicenter prospective observational biobank in Amsterdam, the Netherlands, containing biomaterials (blood, urine, and aneurysm tissue), and clinical and imaging data. Patients with an abdominal aortic diameter of >30 mm or with prior treatment for AAA were eligible for inclusion. Recruitment took place at the outpatient clinic and during hospital admissions. Data were collected during clinical follow-up appointments and surgery. Additionally, a yearly questionnaire and yearly blood and urine samples were collected. In the case of open surgery, aneurysm tissue was collected and stored in the biobank. Results From October 2017 until September 2023, 795 patients with AAA were recruited in Amsterdam UMC. At inclusion, 392 patients had an unrepaired AAA (N=392, 49%), 255 underwent prior AAA repair (N=255, 32%), and 48 were included during hospital admission prior to AAA surgery (N=48, 6%). Blood samples were collected in 696 patients (N=696, 88%). Aneurysm tissue was collected in 53 participants during open repair (N=53, 7%). None of the asymptomatic patients included have experienced AAA rupture. Data have been collected over six years, and ultimately, subgroups will be identified from the total group of patients based on the differences in the natural development of their AAA. Using biomaterials, clinical and imaging data we aim to gain new insights in risk factors for AAA progression and rupture. Conclusion The Pearl-AAA biobank continues to grow and facilitate further AAA research to better predict and perhaps even prevents AAA progression and rupture.
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