Chapter 3 80 3.00) and Turkish origin (RR=2.44, 95%CI=1.92-2.97) had the highest death rates compared to the ethnic-Dutch population, among the largest non-European migrant populations. Sensitivity analysis When restricting to confirmed COVID-19 cases under 60 years of age, individuals with a non-European migration background continued to have an almost five times greater risk of hospitalisation, compared to ethnic-Dutch (RR 4.86, 95%CI=4.59-5.12) (Supplementary Table S7). Regression analyses Multivariable Poisson regression revealed that having a migration background, living in a peripheral city district, male sex and older age were independently associated with higher DSR hospitalisation rates (Table 3). No statistically significant interaction was found between migration background and city district (p=0.21). Table 3. Multivariable Poisson regression model of factors associated with hospitalisation among confirmed COVID-19 cases linked to the population register, Amsterdam, the Netherlands, 15 June 2020-20 January 2021 Characteristic aRR (95% CI) P-value Migration background <0.01 None (ethnic-Dutch) 1 (Ref.) European 1.41 (1.13-1.75) Non-European 4.27 (3.71-4.93) City district <0.01 Central (C/W/S/E) 1 (Ref.) Peripheral (SE/N/NW) 1.42 (1.26-1.41) Sex <0.01 Male 1 (Ref.) Female 0.70 (0.62-0.79) Age, years <0.01 <45 1 (Ref.) 45-59 3.25 (2.68-3.94) 60-74 9.81 (8.29-11.63) ≥75 26.28 (22.02-31.43) Abbreviations: aRR, adjusted rate ratio; CI, confidence interval Estimates were obtained from a multivariable Poisson regression model. We tested for interaction between migration background and city district but this was not significant (p=0.12) so was excluded from the final model. Incidence rates in the Poisson regression model were calculated with the Amsterdam population as the denominator.
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