COVID-19 burden differed by city district and ethnicity during the pre-vaccination era in Amsterdam, the Netherlands 3 75 Figure 2. Flowchart of the inclusion of confirmed COVID-19 cases notified to the Public Health Service of Amsterdam, the Netherlands between 15 June 2020 and 20 January 2021, and linkage of notification data with the municipality register Rates of confirmed COVID-19 case notifications Supplementary Tables S1 and S2 show DSR of confirmed COVID-19 cases per 100,000 population by city district and migration background. After standardizing for age and sex, the rate of confirmed COVID-19 cases per 100,000 population was significantly higher in peripheral city districts compared to central districts (RR=1.30, 95%CI=1.28-1.31). DSR of confirmed cases were the highest in individuals living in New-West (RR=1.56, 95%CI=1.531.60) and South-East (RR=1.45, 95%CI=1.41-1.49), compared to residents of the city center (Supplementary Table S1). Individuals with a non-European background had a 1.4-fold higher DSR of notified infection compared to individuals without a migration background (95%CI=1.40, 95%CI=1.38-1.41), while individuals with a European migration background had a lower DSR compared to individuals without a migration background (RR=0.72, 95%CI=0.69-0.74). DSR of notified infections was highest in individuals from Moroccan (RR=1.88, 95%CI=1.86-1.91) and Turkish origin (RR=1.86, 95%CI=1.82-1.89) (Supplementary Table S2).
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