TABLE OF CONTENTS Chapter 1: General introduction 11 Part 1: Epidemiology and long-term clinical features of COVID-19 in Amsterdam, the Netherlands 34 Chapter 2: Hospitalisation rates differed by city district and ethnicity during the first wave of COVID-19 in Amsterdam, the Netherlands 37 Chapter 3: COVID-19 burden differed by city district and ethnicity during the pre-vaccination era in Amsterdam, the Netherlands 67 Chapter 4: Evolution of COVID-19 symptoms during the first 12 months after illness onset 97 Chapter 5: Severe fatigue in the first year following SARS-CoV-2 infection: A prospective cohort study 135 Part 2: In-depth characterisation of long COVID: Trajectories and possible pathogenesis 170 Chapter 6: Two-year trajectories of COVID-19 symptoms and their association with illness perception: A prospective cohort study in Amsterdam, the Netherlands 172 Chapter 7: Inflammatory profiles are associated with long COVID up to 6 months after illness onset: a prospective cohort study of patients with mild to critical COVID-19 207 Chapter 8: The effect of SARS-CoV-2 vaccination on post-acute COVID-19 syndrome (PASC): A prospective cohort study 239 Chapter 9: General discussion 269 Chapter 10: Summaries in English and Dutch 299 Appendix 311
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