The effect of SARS-CoV-2 vaccination on post-acute COVID-19 syndrome (PASC): A prospective cohort study 8 247 Table 1. Socio-demographic, clinical and study features of RECoVERED study participants with at least 3 months of follow-up, stratified by those who did and did not develop PASC Total PASC status No PASC PASC p-value N=316 N=130 N=186 Sex 0.20 Male 181 (57%) 80 (62%) 101 (54%) Female 135 (43%) 50 (38%) 85 (46%) Age, years 51.0 (36.0-62.0) 46.0 (32.0-57.0) 53.5 (41.0-64.0) <0.001 Clinical severity score <0.001 Mild 92 (29%) 61 (47%) 31 (17%) Moderate 142 (45%) 52 (40%) 90 (48%) Severe/critical 82 (26%) 17 (13%) 65 (35%) BMI, kg/m2 26.0 (23.2-29.4) 25.1 (22.9-27.7) 26.8 (23.7-31.0) 0.0020 BMI category 0.027 Normal weight 130 (41%) 62 (48%) 68 (37%) Overweight 105 (33%) 43 (33%) 62 (33%) Obese 71 (22%) 20 (15%) 51 (27%) Missing 10 (3%) 5 (4%) 5 (3%) Migration background 0.25 Dutch 187 (59%) 78 (60%) 109 (59%) Non-Dutch, OECD high- income 39 (12%) 20 (15%) 19 (10%) Non-Dutch, OECD low/ middle income 74 (23%) 26 (20%) 48 (26%) Missing 16 (5%) 6 (5%) 10 (5%) Highest level of education <0.001 None, primary or secondary education 42 (13%) 8 (6%) 34 (18%) Vocational training 73 (23%) 24 (18%) 49 (26%) University education 181 (57%) 93 (72%) 88 (47%) Missing 20 (6%) 5 (4%) 15 (8%) Number of COVID-19 highrisk comorbidities 0.035 0 178 (56%) 85 (65%) 93 (50%) 1 73 (23%) 27 (21%) 46 (25%) 2 37 (12%) 10 (8%) 27 (15%) 3 or more 28 (9%) 8 (6%) 20 (11%) Place of recruitment <0.001 Non-hospital (PHSA) 156 (49%) 93 (72%) 63 (34%) Hospital 160 (51%) 37 (28%) 123 (66%) Days from illness onset to COVID-19 diagnosis 5 (2-10) 4 (2-8) 6 (2-11) 0.064 Days from illness onset to inclusion in study 12 (6-42) 9 (5-17) 17 (9-80) <0.001
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