Chapter 7 236 Supplementary Figure S5. Multivariate linear regression analysis of factors associated with inflammatory marker concentrations at 21-24 weeks after COVID-19 illness onset, including abnormal lung function (impaired diffusion capacity) For each inflammatory marker, we performed a mixed effects linear regression of various factors: characteristics present prior to COVID-19 illness onset, COVID-19-related factors, and post-COVID-19 related factors. Characteristics present prior to COVID-19 illness onset included sex, age (≥60 or <60 years old), body mass index (BMI) ≥ 30, and the presence of comorbidities (including cardiovascular disease, diabetes mellitus, chronic pulmonary disease or current cancer). COVID-19-related factors included the severity of initial COVID-19 disease, if dexamethasone was administered, and current (at 24 weeks) presence of abnormal lung function (impaired diffusion capacity [DLCO]). Post-COVID-19 related factors included measurement of inflammatory markers within four weeks after SARS-CoV-2 vaccination. Statistically significant negative effects (associations with lower cytokine concentrations) are shown in red whilst positive effects (associations with higher cytokine levels) are shown in blue.
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