Inflammatory profiles are associated with long COVID up to 6 months after illness onset: A prospective cohort study of patients with mild to critical COVID-19 7 231 Supplementary Table S2. Concentration distribution of soluble inflammatory markers across different time-points among individuals with COVID-19 and health controls Persons with COVID-19 Healthy controls Marker Weeks since symptom onset Median 25th percentile 75th percentile p* Median 25th percentile 75th percentile CRP (log pg/ml) ≤4 6.39 5.86 7.21 0.094 6.07 5.80 6.36 9-12 5.93 5.46 6.45 0.432 21-24 5.99 5.51 6.37 0.432 sCD14 (log pg/ml) ≤4 6.27 6.12 6.38 p<0.001 6.72 6.34 6.95 9-12 6.13 6.01 6.21 p<0.001 21-24 6.09 6.00 6.18 p<0.001 MCP1 (log pg/ml) ≤4 2.73 2.59 2.87 0.351 2.66 2.60 2.75 9-12 2.65 2.54 2.80 0.48 21-24 2.60 2.51 2.77 0.202 IP-10 (log pg/ml) ≤4 1.83 1.60 2.05 p<0.001 1.23 1.12 1.32 9-12 1.27 1.11 1.45 0.48 21-24 1.17 1.00 1.28 0.094 IL-10 (log pg/ml) ≤4 3.86 3.10 4.14 p<0.001 -1.00 -1.00 -1.00 9-12 3.00 -1.00 3.10 p<0.001 21-24 -1.00 -1.00 -0.79 0.006 IL-17 (log pg/ml) ≤4 2.00 2.00 2.45 p<0.001 0.00 0.00 0.00 9-12 2.00 0.70 2.00 p<0.001 21-24 0.00 0.00 0.00 0.04 sCD163 (log pg/ml) ≤4 5.79 5.60 5.98 0.202 5.65 5.53 5.88 9-12 5.73 5.60 5.93 0.432 21-24 5.78 5.64 5.93 0.265 IL-1β (log pg/ml) ≤4 0.85 0.15 1.70 p<0.001 0.15 0.15 0.15 9-12 0.15 0.15 1.11 p<0.001 21-24 0.15 0.15 1.04 p<0.001 IL-6 (log pg/ml) ≤4 3.38 2.55 4.32 p<0.001 0.50 0.21 0.50 9-12 2.00 0.86 3.12 p<0.001 21-24 0.59 0.08 1.60 0.047 TNF-α (log pg/ml) ≤4 3.21 2.88 3.69 p<0.001 0.36 0.36 0.73 9-12 2.48 1.13 2.93 p<0.001 21-24 0.57 0.06 1.03 0.283 IL-2 (log pg/ml) ≤4 0.30 0.30 0.54 0.202 0.30 0.30 0.30 9-12 0.30 0.30 0.30 0.005 21-24 0.30 0.30 0.30 p<0.001 IL-13 (log pg/ml) ≤4 1.48 1.48 1.91 0.477 1.48 1.48 1.48 9-12 1.48 1.48 1.48 0.265 21-24 1.48 1.48 1.88 0.004 *Mann-Whitney U test between measurements at each binned time period of infected individuals and those measured from healthy controls with multiple testing correction using the Bonferroni method.
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