Two-year trajectories of COVID-19 symptoms and their association with illness perception: A prospective cohort study in Amsterdam, the Netherlands 6 199 Supplementary Table S7. Median (interquartile range) illness perception sub-domain scores by trajectory of the mean total number of long COVID symptoms Total Trajectory 1 Trajectory 2 Trajectory 3 Trajectory 4 p-value Month 1 N 209 54 97 36 29 Consequences 5 (2-8) 3 (1-5) 5 (2-7) 8 (6-9) 8 (7-10) <0.001 Timeline 3 (1-5) 2 (0-3) 3 (2-5) 4 (3-6) 5 (4-5) <0.001 Personal control 5 (2-6) 4 (1-6) 4 (2-6) 5 (4-6) 5 (5-7) 0.061 Treatment control 5 (4-8) 5 (2-8) 5 (3-9) 5 (4-6) 5 (4-7) 0.99 Identity 4 (1-6) 1 (0-3) 4 (2-6) 5 (4-7) 6 (5-8) <0.001 Concern 3 (1-6) 1 (0-3) 3 (1-6) 5 (3-7) 5 (3-8) <0.001 Comprehension 4 (1-5) 2 (0-5) 3 (1-5) 5 (4-6) 3 (2-5) 0.014 Emotions 4 (1-5) 4 (0-5) 4 (1-5) 5 (3-7) 5 (3-7) 0.002 Month 6 N 242 54 111 55 22 Consequences 4 (1-7) 1 (0-4) 3 (1-6) 5 (2-8) 6 (5-9) <0.001 Timeline 3 (1-5) 1 (0-3) 3 (1-5) 4 (3-6) 5 (5-6) <0.001 Personal control 4 (1-6) 2 (0-5) 4 (1-5) 5 (2-7) 5 (5-7) 0.001 Treatment control 5 (3-9) 8 (2-10) 5 (2-9) 5 (3-6) 5 (3-8) 0.11 Identity 2 (1-6) 0 (0-1) 2 (1-5) 5 (2-6) 7 (5-8) <0.001 Concern 2 (0-5) 0 (0-1) 2 (0-6) 3 (2-6) 5 (3-8) <0.001 Comprehension 3 (1-5) 1 (0-5) 3 (2-5) 4 (1-7) 5 (3-7) <0.001 Emotions 2 (1-5) 1 (0-3) 2 (0-5) 4 (2-5) 6 (3-7) <0.001 Month 12 N 223 52 101 49 21 Consequences 2 (0-6) 1 (0-2) 2 (0-6) 5 (2-8) 7 (5-9) <0.001 Timeline 2 (0-5) 0 (0-2) 2 (0-5) 5 (2-7) 5 (4-7) <0.001 Personal control 4 (1-7) 5 (1-10) 3 (0-5) 5 (2-7) 5 (5-7) 0.009 Treatment control 5 (2-9) 5 (2-10) 5 (2-9) 5 (2-6) 5 (5-7) 0.45 Identity 2 (0-6) 0 (0-1) 1 (0-6) 4 (1-6) 5 (4-8) <0.001 Concern 2 (0-5) 0 (0-1) 1 (0-5) 4 (1-6) 5 (3-8) <0.001 Comprehension 4 (1-6) 2 (0-5) 4 (1-5) 4 (2-6) 5 (4-7) 0.018 Emotions 1 (0-5) 0 (0-2) 1 (0-5) 3 (1-6) 6 (4-7) <0.001 P-value denotes outcome of Kruskal-Wallis tests. Long COVID symptoms were defined as those developing within 1 month of overall illness onset, in order to exclude sporadic symptoms that were less likely to be attributed to the consequences of COVID-19. Trajectory group membership based on the maximum a posteriori probability of belonging to that group.
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