Two-year trajectories of COVID-19 symptoms and their association with illness perception: A prospective cohort study in Amsterdam, the Netherlands 6 195 Inclusion status in current analyses Total Excluded Included p-value N=349 N=57 N=292 ICU admission 45 (13%) 5 (9%) 40 (14%) 0.39 Days from illness onset to COVID-19 diagnosis 4 (2-10) 6 (2-9) 4 (2-10) 0.38 Days from illness onset to hospitalisation 9 (7-14) 8 (3-14) 9 (7-14) 0.23 Days from illness onset to ICU admission 10 (7-12) 8 (6-9) 10 (7-12) 0.11 Received oxygen therapy before or during follow-up 169 (49%) 34 (63%) 135 (46%) 0.024 Maximal HR, beats/min 83 (72-94) 84 (72-96) 82 (72-94) 0.66 Maximal RR, breaths/min 20 (16-24) 20 (16-25) 20 (16-24) 0.34 Lowest SpO2, % 96 (91-98) 95 (88-98) 96 (91-98) 0.38 Vaccinated during follow-up (primary series) NA Not vaccinated 25 (7%) 1 (2%) 24 (8%) Vaccinated 233 (67%) 1 (2%) 232 (79%) LTFU before vaccination 91 (26%) 55 (96%) 36 (12%) Died during follow-up 5 (1%) 4 (7%) 1 (0%) NA Number of reinfections NA 0 278 (80%) 56 (98%) 222 (76%) 1 66 (19%) 1 (2%) 65 (22%) 2 or more 5 (1%) 0 (0%) 5 (1%) PASC at 12 weeks after illness onset <0.001 Recovered within 12 weeks 126 (36%) 11 (19%) 115 (39%) Did not recover within 12 weeks 205 (59%) 28 (49%) 177 (61%) LTFU within 12 weeks 18 (5%) 18 (32%) 0 (0%) Study characteristics Place of recruitment 0.016 Non-hospital 161 (46%) 18 (32%) 143 (49%) Hospital 188 (54%) 39 (68%) 149 (51%) Type of inclusion 0.048 Prospective 257 (74%) 48 (84%) 209 (72%) Retrospective 92 (26%) 9 (16%) 83 (28%) Days from illness onset to inclusion in study 12 (6-38) 11 (7-20) 12 (6-51) 0.41 Lost to follow-up 164 55 109 NA Abbreviations: BMI, body mass index; COVID-19, coronavirus disease 2019; HR, heart rate; ICU, intensive care unit; LTFU, lost to follow-up; OECD, Organisation for Economic Co-operation and Development; NA, not applicable; PCR, polymerase chain reaction; SpO2, oxygen saturation on room air; RR, respiratory rate; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2. Continuous variables presented as median (IQR) and compared using the Kruskal-Wallis test; categorical and binary variables presented as n(%) and compared using the Pearson χ 2 test (or Fisher exact test if n <5).
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