Chapter 6 184 Symptom trajectory number Total 1 2 3 4 p-value N=290* N=70 N=137 N=59 N=24 Vaccination status (primary series) NA Not vaccinated 24 (8%) 3 (4%) 8 (6%) 8 (14%) 5 (21%) Vaccinated 231 (80%) 59 (84%) 109 (80%) 47 (80%) 16 (67%) LTFU before vaccination 35 (12%) 8 (11%) 20 (15%) 4 (7%) 3 (13%) Died during follow-up 1 (0%) 1 (1%) 0 (0%) 0 (0%) 0 (0%) 0.53 Number of reinfections 0.58 0 231 (80%) 57 (81%) 112 (82%) 45 (76%) 17 (71%) 1 55 (19%) 13 (19%) 23 (17%) 12 (20%) 7 (29%) 2 or more 4 (1%) 0 (0%) 2 (1%) 2 (4%) 0 (0%) Long COVID status at 12 weeks after illness onset <0.001 No (recovered within 12 weeks) 121 (42%) 53 (76%) 57 (42%) 9 (15%) 2 (8%) Yes (did not recover within 12 weeks) 169 (58%) 17 (24%) 80 (58%) 50 (85%) 22 (92%) Abbreviations: BMI, body mass index; COVID-19, coronavirus disease 2019; HR, heart rate; ICU, intensive care unit; LTFU, lost to follow-up; OECD, Organisation for Economic Co-operation and Development; NA, not applicable; PCR, polymerase chain reaction; SpO2, oxygen saturation on room air; RR, respiratory rate; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2. * Two individuals could not be assigned to a trajectory group due to missing risk variable (BMI). Continuous variables presented as median (IQR) and compared using the Kruskal-Wallis test; categorical and binary variables presented as n(%) and compared using the Pearson χ 2 test (or Fisher exact test if n <5). COVID-related comorbidities are based on WHO Clinical Management Guidelines and include: cardiovascular disease (including hypertension), chronic pulmonary disease (excluding asthma), renal disease, liver disease, cancer, immunosuppression (excluding HIV, including previous organ transplantation), previous psychiatric illness and dementia. Physical measurements at D0 and D7 study visits. Oxygen saturation measured on room air if possible or retrieved from ambulance records for hospitalised participants admitted on oxygen on day of enrollment. Trajectory group membership was based on the maximum a posteriori probability of belonging to that group. Time-dependent outcomes not compared between groups due to bias resulting from differing follow-up lengths. When modelling the finite-mixture distribution of profile membership from the multivariable GBTM (Table 3), participants who were obese had higher odds of belonging to Trajectory 3 (p=0.038) or 4 (p=0.029) than Trajectory 1. Additionally, female participants had higher odds of belonging to Trajectory 2, 3 or 4 than participants in Trajectory 1 when adjusting for other covariates. Individuals infected on or after 1 June 2020 instead of during the first wave of COVID-19 had a 5-times higher odds of belonging to Trajectory
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