Chapter 6 180 Initial COVID-19 severity Total Mild Moderate Severe/ critical p- value N=292 N=86 N=127 N=79 Number of COVID-19 highrisk comorbidities <0.001 0 160 (55%) 61 (71%) 75 (59%) 24 (30%) 1 72 (25%) 18 (21%) 28 (22%) 26 (33%) 2 36 (12%) 5 (6%) 16 (13%) 15 (19%) 3 or more 24 (8%) 2 (2%) 8 (6%) 14 (18%) COVID-19-related clinical characteristics Symptom status at baseline 0.45 Symptomatic 287 (98%) 85 (99%) 127 (100%) 75 (95%) Asymptomatic 2 (1%) 1 (1%) 0 (0%) 1 (1%) Missing 3 (1%) 0 (0%) 0 (0%) 3 (4%) Hospital admission 141 (48%) 4 (5%) 60 (47%) 77 (97%) <0.001 ICU admission 40 (14%) 0 (0%) 0 (0%) 40 (51%) <0.001 Days from illness onset to COVID-19 diagnosis 4 (2-10) 3 (1-8) 4 (2-11) 7 (2-11) 0.13 Days from illness onset to hospitalisation 9 (7-14) 43 (9-85) 10 (8-16) 9 (7-12) 0.10 Days from illness onset to ICU admission 10 (7-12) NA NA 10 (7-12) Received oxygen therapy before or during follow-up 135 (46%) 0 (0%) 59 (46%) 76 (96%) <0.001 Received steroid treatment <0.001 No steroid 211 (72%) 86 (100%) 88 (69%) 37 (47%) Dexamethasone 55 (19%) 0 (0%) 27 (21%) 28 (35%) Other steroid 26 (9%) 0 (0%) 12 (9%) 14 (18%) Maximal HR, beats/min 82 (72-94) 75 (67-81) 84 (76-94) 94 (79-107) <0.001 Maximal RR, breaths/min 20 (16-24) 16 (16-16) 20 (20-24) 24 (20-32) <0.001 Lowest SpO2, % 96 (91-98) 98 (97-99) 96 (93-98) 88 (80-90) <0.001 Received COVID-19 primary vaccination series NA Not vaccinated 24 (8%) 2 (2%) 13 (10%) 9 (11%) Vaccinated 232 (79%) 72 (84%) 102 (80%) 58 (73%) LTFU before vaccination 36 (12%) 12 (14%) 12 (9%) 12 (15%) Time from illness onset to first vaccination, days 244 (139-360) 203 (130-310) 241 (162-318) 372 (131-393) NA Died during follow-up 1 (0%) 0 (0%) 1 (1%) 0 (0%) NA Number of reinfections NA 0 222 (76%) 57 (66%) 92 (72%) 73 (92%) 1 65 (22%) 27 (31%) 33 (26%) 5 (6%) 2 or more 5 (1%) 2 (2%) 2 (2%) 1 (1%)
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