Two-year trajectories of COVID-19 symptoms and their association with illness perception: A prospective cohort study in Amsterdam, the Netherlands 6 179 at least one symptom questionnaire and were included in the current analysis (Table 1). Participants who completed at least one symptom questionnaire were more likely to be of Dutch background (p=0.003) and less likely to have been hospitalised due to COVID-19 (p=0.013) (Supplementary Table S1). Most (264/349; 75.6%) study participants were recruited prior to 1 January 2021, prior to when the Alpha variant (B1.1.7) began to circulate in the Netherlands[15]. Table 1. Socio-demographic, clinical and study characteristics of participants enrolled between May 2020-June 2021 who completed at least one symptom survey in the RECoVERED cohort in Amsterdam, the Netherlands Initial COVID-19 severity Total Mild Moderate Severe/ critical p- value N=292 N=86 N=127 N=79 Baseline socio-demographic and medical characteristics Sex 0.25 Male 170 (58%) 44 (51%) 76 (60%) 50 (63%) Female 122 (42%) 42 (49%) 51 (40%) 29 (37%) Age, years 51.0 (36.0-62.0) 41.0 (29.0-54.0) 50.0 (34.0-62.0) 60.0 (51.0-66.0) <0.001 BMI, kg/m2 26.1 (23.5-29.4) 24.5 (22.8-27.7) 26.2 (23.5-29.4) 27.4 (25.5-33.3) <0.001 BMI category <0.001 Normal weight 121 (41%) 50 (58%) 52 (41%) 19 (24%) Overweight 101 (35%) 23 (27%) 45 (35%) 33 (42%) Obese 68 (23%) 13 (15%) 30 (24%) 25 (32%) Missing 2 (1%) 0 (0%) 0 (0%) 2 (3%) Migration background 0.003 Dutch 183 (63%) 62 (72%) 77 (61%) 44 (56%) Non-Dutch, OECD high- income 31 (11%) 11 (13%) 16 (13%) 4 (5%) Non-Dutch, OECD low/ middle income 71 (24%) 10 (12%) 32 (25%) 29 (37%) Missing 7 (2%) 3 (3%) 2 (2%) 2 (3%) Smoking 0.13 Non-smoker 182 (62%) 52 (60%) 74 (58%) 56 (71%) Smoker 19 (7%) 8 (9%) 10 (8%) 1 (1%) Ex-smoker 88 (30%) 24 (28%) 43 (34%) 21 (27%) Missing 3 (1%) 2 (2%) 0 (0%) 1 (1%) Highest level of education <0.001 None, primary or secondary education 41 (14%) 7 (8%) 22 (17%) 12 (15%) Vocational training 70 (24%) 9 (10%) 32 (25%) 29 (37%) University education 173 (59%) 67 (78%) 71 (56%) 35 (44%) Missing 8 (3%) 3 (3%) 2 (2%) 3 (4%)
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