Severe fatigue in the first year following SARS-CoV-2 infection: A prospective cohort study 5 169 COVID-19 clinical severity defined as follows: mild disease as having a RR<20/min and SpO2>94% on room air at both D0 and D7 study visits; moderate disease as having a RR20-30/min and SpO2 9094% or receiving oxygen therapy at D0 and/or D7 study visits; severe disease as having a RR>30/min and SpO2<90% or receiving oxygen therapy at D0 and/or D7 study visits; critical disease as requiring ICU admission as a result of COVID-19 at any point. COVID-related comorbidities are based on WHO Clinical Management Guidelines[16] and include: cardiovascular disease (including hypertension), chronic pulmonary disease (excluding asthma), renal disease, liver disease, cancer, immunosuppression (excluding HIV, including previous organ transplantation), previous psychiatric illness and dementia. Highest baseline sadness score defined as the highest reported level of sadness at D0 or D7, subjectively reported on a scale from 0 to 10. Acute presence of dyspnoea defined as reporting dyspnoea during the first two weeks after overall illness onset.
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