Elke Wynberg

Chapter 5 160 Determinant (selected a priori) Univariable analysis Multivariable Model 1 Multivariable Model 2 Multivariable Model 3 β coef. (95% CI) p-value β coef. (95% CI) p-value β coef. (95% CI) p-value β coef. (95% CI) p-value Clinical severity Clinical severity*** <0.001 <0.001 0.002 Mild Ref. NA NA Ref. Ref. Moderate 3.39 (1.73-5.05) NA NA 3.09 (1.40-4.78) 1.92 (0.24-3.61) Severe/critical 4.72 (2.81-6.62) NA NA 3.98 (1.84-6.11) 3.33 (1.19-5.46) Clinical features of COVID-19 Highest baseline sadness score**** <0.001 NA NA NA NA 0.028 0-1 Ref. NA NA NA NA Ref. 2-5 0.89 (-0.79-2.57) NA NA NA NA 0.71 (-1.05-2.47) 6-10 4.23 (2.47-6.00) NA NA NA NA 2.15 (0.17-4.13) Highest baseline anxiety score**** <0.001 NA NA NA NA 0.059 0-1 Ref. NA NA NA NA Ref. 2-5 0.95 (-0.75-2.64) NA NA NA NA 0.41 (-1.39-2.21) 6-10 4.15 (2.40-5.90) NA NA NA NA 1.98 (0.02-3.94) Presence of acute fatigue¶ 1.54 (-0.27-3.36) 0.096 NA NA NA NA -1.83 (-4.54-0.90) 0.233 Presence of acute myalgia 1.60 (0.16-3.06) 0.030 NA NA NA NA 0.65 (-1.09-2.40) 0.626 Presence of acute headache 1.73 (0.28-3.18) 0.019 NA NA NA NA 1.58 (-0.22-3.37) 0.083 Presence of acute dyspnoea 3.72 (2.31-5.13) <0.001 NA NA NA NA 2.25 (0.43-4.08) 0.013 Presence of acute cough 1.32 (-0.17-2.81) 0.083 NA NA NA NA 0.02 (-1.80-1.85) 0.912 Presence of acute fever 1.49 (0.17-2.95) 0.047 NA NA NA NA 0.34 (-1.44-2.13) 0.630 Covariates selected for final models, in addition to age and sex: NA BMI group, number of high-risk COVID-19 comorbidities at illness onset, migration background Number of high-risk COVID-19 comorbidities at illness onset, clinical severity Number of high-risk COVID-19 comorbidities at illness onset, clinical severity, baseline sadness score, presence of acute dyspnoea

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