Severe fatigue in the first year following SARS-CoV-2 infection: A prospective cohort study 5 159 Supplementary Table S2. Selection of determinants for inclusion in linear mixed-effects models, by model type Determinant (selected a priori) Univariable analysis Multivariable Model 1 Multivariable Model 2 Multivariable Model 3 β coef. (95% CI) p-value β coef. (95% CI) p-value β coef. (95% CI) p-value β coef. (95% CI) p-value Socio-demographic and medical characteristics at illness onset Age per 10 year increase, years 0.30 (-0.17-0.77) 0.212 -0.26 (-0.82-0.31) 0.393 -0.29 (-0.83-0.24) 0.198 -0.18 (-0.74-0.37) 0.442 Sex 0.040 0.044 0.114 Male Ref. Ref. Ref. Ref. Female 1.53 (0.07-3.00) 1.63 2.03 (0.57-3.49) 0.014 1.26 (-0.17-2.70) BMI group 0.002 0.037 0.062 NA NA Normal weight Ref. Ref. Ref. NA NA Overweight 2.45 (0.80-4.10) 2.08 (0.36-3.79) 1.71 (0.03-3.40) NA NA Obese 2.71 (0.83-4.58) 2.00 (0.02-3.99) 1.80 (-0.11-3.71) NA NA Number of high-risk COVID-19 comorbidities at illness onset* <0.001 0.003 0.016 0.007 0 Ref. Ref. Ref. Ref. 1 1.59 (-.017-3.35) 1.47 (-0.46-3.41) 1.11 (-0.79-3.01) 0.39 (-0.14-2.22) 2 1.57 (-0.67-3.81) 1.11 (-1.31-3.53) 0.57 (-0.18-2.94) 0.72 (-1.61-3.04) 3+ 5.35 (2.68-8.02) 4.50 (1.60-7.41) 4.26 (1.41-7.11) 4.69 (1.90-7.48) Smoking 0.775 NA NA NA NA NA NA Non-smoker Ref. NA NA NA NA NA NA Ex-smoker -0.84 (-3.81-2.13) NA NA NA NA NA NA Current smoker -0.20 (-1.83-1.44) NA NA NA NA NA NA Migration background** 0.004 0.018 0.058 NA NA Dutch Ref. Ref. Ref. NA NA Non-Dutch, OECD high-income 1.41 (-0.88-3.69) 1.99 (-0.27-4.24) 1.59 (-0.61-3.78) NA NA Non-Dutch, OECD LMIC 2.49 (0.75-4.24) 1.73 (-0.06-3.52) 1.28 (-0.45-3.01) NA NA Highest educational level 0.001 0.174 NA NA NA NA None, primary or secondary only Ref. Ref. NA NA NA NA Vocational training 0.45 (-1.96-2.86) 1.25 (-1.16-3.66) NA NA NA NA University-level education -2.62 (-4.75- -0.49) -1.00 (-3.34-1.33) NA NA NA NA
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