Chapter 5 142 Total Mild COVID-19 Moderate COVID-19 Severe/critical COVID-19 p- value N=303 N=88 N=136 N=79 Number of COVID-19 high-risk comorbidities *** <0.001 0 168 (55%) 63 (72%) 81 (60%) 24 (30%) 1 71 (23%) 17 (19%) 29 (21%) 25 (32%) 2 38 (13%) 5 (6%) 17 (13%) 16 (20%) 3 or more 26 (9%) 3 (3%) 9 (7%) 14 (18%) Cardiovascular disease 81 (27%) 12 (14%) 33 (24%) 36 (46%) <0.001 Diabetes 34 (11%) 5 (6%) 11 (8%) 18 (23%) <0.001 Chronic respiratory disease 20 (7%) 1 (1%) 8 (6%) 11 (14%) 0.003 Cancer 17 (6%) 6 (7%) 7 (5%) 4 (5%) 0.85 Immunosuppressed 6 (2%) 0 (0%) 3 (2%) 3 (4%) 0.20 Psychiatric illness 18 (6%) 5 (6%) 9 (7%) 4 (5%) 0.90 Other comorbidities 64 (21%) 11 (13%) 34 (25%) 19 (24%) 0.063 Clinical features of SARS-CoV-2 infection Symptom status at baseline 0.44 Symptomatic 302 (100%) 87 (99%) 136 (100%) 79 (100%) Asymptomatic 1 (0%) 1 (1%) 0 (0%) 0 (0%) Hospital admission 144 (48%) 4 (5%) 64 (47%) 76 (96%) <0.001 ICU admission 39 (13%) 0 (0%) 0 (0%) 39 (49%) <0.001 Days from illness onset to SARS-CoV-2 diagnosis 4 (2-10) 3 (1-8) 5 (2-11) 7 (2-11) 0.078 Days from illness onset to hospitalisation 9 (7-14) 24 (9-66) 9 (8-15) 9 (7-13) 0.24 Days from illness onset to ICU admission 10 (8-12) NA NA 10 (8-12) Received oxygen therapy before or during follow-up 137 (45%) 0 (0%) 63 (46%) 74 (95%) <0.001 Physical measurements **** Maximal HR, beats/min 82 (72-94) 76 (66-81) 84 (76-94) 94 (79-107) <0.001 Maximal RR, breaths/ min 20 (16-24) 16 (16-16) 20 (20-24) 25 (20-32) <0.001 Lowest SpO2, % 96 (92-98) 98 (97-99) 96 (93-98) 88 (81-90) <0.001 Highest baseline sadness score ¥ <0.001 0-1 125 (41%) 40 (45%) 44 (32%) 41 (52%) 2-5 90 (30%) 35 (40%) 43 (32%) 12 (15%) 6-10 81 (27%) 13 (15%) 45 (33%) 23 (29%) Missing 7 (2%) 0 (0%) 4 (3%) 3 (4%)
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