Elke Wynberg

Chapter 4 118 Univariable model Multivariable model Number of comorbidities <0.01 0.30 0 Ref. Ref. 1 0.59 0.40-0.88 0.71 0.46-1.08 2 0.51 0.29-0.89 0.68 0.37-1.24 3 or more 0.50 0.25-1.00 0.68 0.31-1.46 Dyspnoea Baseline variable HR 95% CI p-value HR 95% CI p-value Age, years (per 10 year increase) 0.75 0.66-0.84 <0.01 0.80 0.69-0.93 <0.01 Sex 0.09 Male Ref. Ref. Female 0.85 0.60-1.21 0.37 0.72 0.49-1.05 BMI, kg/m2 <0.01 0.07 Normal weight Ref. Ref. Overweight 0.78 0.52-1.16 0.77 0.51-1.17 Obese 0.47 0.29-0.76 0.57 0.34-0.94 Number of comorbidities 0.02 0.78 0 Ref. Ref. 1 0.66 0.43-1.02 0.93 0.58-1.50 2 0.49 0.28-0.88 0.74 0.40-1.38 3 or more 0.54 0.29-1.02 0.79 0.39-1.62 Comorbidities counted are those listed by the WHO as being associated with a higher risk of developing severe or critical COVID-19[11], excluding BMI. BMI categorised in kg/m2 as: <25, underweight or normal weight; 25 up to 30, overweight; >30, obese. *Age included as a time-varying covariate in the multivariable model of time to recovery from fatigue, to ensure the proportional hazards assumption was met.

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