Evolution of COVID-19 symptoms during the first 12 months after illness onset 4 117 Table S2. Association between age, sex, BMI and number of comorbidities at illness onset and time to recovery from fatigue, loss of smell and/or taste, myalgia and dyspnoea in univariable and multivariable Cox proportional hazard models Univariable model Multivariable model Fatigue Baseline variable HR 95% CI p-value HR 95% CI p-value Age, years (per 10 year increase)* 0.84 0.76-0.93 <0.01 1.00* 1.00-1.00 0.02 Sex 0.12 Male Ref. Female 0.84 0.62-1.13 0.25 0.78 0.57-1.07 BMI, kg/m2 0.07 Normal weight Ref. 0.05 Ref. Overweight 0.73 0.52-1.03 0.73 0.52-1.03 Obese 0.64 0.44-0.95 0.66 0.44-0.98 Number of comorbidities 0.02 <0.01 0 Ref. Ref. 1 0.60 0.42-0.87 0.51 0.34-0.76 2 0.70 0.43-1.14 0.68 0.41-1.13 3 or more 0.59 0.34-1.02 0.48 0.26-0.86 Loss of smell and/or taste Baseline variable HR 95% CI p-value HR 95% CI p-value Age, years (per 10 year increase) 0.92 0.84-1.02 0.14 0.92 0.82-1.04 0.19 Sex 0.25 0.18 Male Ref. Ref. Female 0.83 0.60-1.14 0.80 0.58-1.11 BMI, kg/m2 0.03 0.02 Normal weight Ref. Ref. Overweight 0.87 0.61-1.24 0.83 0.57-1.20 Obese 0.56 0.36-0.87 0.51 0.32-0.82 Number of comorbidities 0.49 0.35 0 Ref. Ref. 1 0.81 0.55-1.20 0.96 0.62-1.45 2 0.76 0.43-1.33 1.03 0.56-1.88 3 or more 1.22 0.64-2.36 1.92 0.92-4.02 Myalgia Baseline variable HR 95% CI p-value HR 95% CI p-value Age, years (per 10 year increase) 0.75 0.67-0.85 <0.01 0.78 0.68-0.89 <0.01 Sex 0.41 0.49 Male Ref. Ref. Female 0.87 0.63-1.21 0.88 0.62-1.25 BMI, kg/m2 0.10 0.22 Normal weight Ref. Ref. Overweight 1.01 0.70-1.46 0.98 0.67-1.44 Obese 0.66 0.42-1.02 0.70 0.44-1.09
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