Evolution of COVID-19 symptoms during the first 12 months after illness onset 4 107 days (Figure 1), although 16.4%(95%CI=8.5-26.5%) continued to report at least one ongoing symptom at twelve months after illness onset. In those with moderate disease, median time to complete recovery was 232 days (7.6 months) and 49.5% (95%CI=39.6-58.6%) continued to report at least one symptom at 12 months after illness onset. More than half of those with severe/critical disease reported at least one ongoing symptom at twelve months after illness onset (52.5%[95%CI=38.0-65.1%]. Supplementary Figures S4a-e show Kaplan-Meier estimates for the individual 18 symptoms, by clinical severity group. Participants who were vaccinated while still having symptoms (n=91, median time from onset of symptoms to vaccination 249 days [IQR 142-365]) were right-censored at date of first vaccination. Figure 1. Kaplan-Meier estimates of time from illness onset to complete recovery from symptoms, by clinical severity group Kaplan-Meier estimates of time from illness onset to complete recovery from symptoms, by clinical severity group. Clinical severity groups of severe and critically severe COVID-19 combined due to small numbers. Dashed red vertical line denotes 12 weeks (cutoff point for post-COVID syndrome, as per NICE definition); black vertical lines indicate time-points at which participants were censored. Participants who were vaccinated while still having symptoms (n = 91, median time from onset of symptoms to vaccination 249 days [IQR 142-365]) were right-censored at date of first vaccination. Curves represent the percentages of study participants recovering from symptoms during 1 year after COVID-19 illness onset. Shaded areas represent 95% CIs. The numbers of individuals at risk during each 28-day interval since illness onset are given below the graph. Abbreviations: CI, confidence interval; COVID-19, coronavirus disease 2019; NICE, National Institute for Health and Care Excellence.
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