Part III ♥ 182 Borrowing from treatment groups through expanded access As expanded access programs are the focus of our thesis, we explored whether we could extend the ideas of borrowing historical information from control groups into current control arms, to borrowing information from expanded access programs into current treatment arms. The following paper explores these ideas statistically, but Figure 1 provides the reader a graphical sketch. CONTROL GROUP TREATMENT GROUP HISTORIC TRIAL RCT EAP + + Figure 1: Graphical representation of augmenting current randomized clinical trial (RCT) control groups with historical control groups or augmenting current trial treatment groups with expanded access program (EAP) patients.
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