Chapter 7 136 Table 6: Top ten endpoints reported in COVID-19 related expanded publications. Endpoint Occurrence (%) of articles Terms used in the publications Adverse Events 57 Adverse events, TESAEs, Serious adverse events, abnormal laboratory measurements (primarily regarding liver function, e.g., ALT, AST) Mortality 45 All-cause 28-day mortality, survival, crude mortality, death, mortality rate Inflammatory markers 34 IL-6, pro-inflammatory biomarkers, NK-cell count, leukocyte counts, immune monitoring, cytokine response, inflammatory mediators, biomarkers associated with complement activation, CRP, fibrinogen, D-dimer, urea, ferritin, LDH Oxygen support 32 Oxygen requirement, supplemental oxygen, return to room air (RTRA), oxygenation Clinical improvement 26 SAPS II score, multi organ dysfunction score (MODS), disease severity score, clinical improvement meeting the discharge criteria, physician-reported clinical status, successful clinical outcome, clinical recovery, clinical status, clinical cure, Sepsis-related Organ Failure Assessment (SOFA) Score Hospital discharge rate 26 Hospital discharge rate, duration in hospital, days in hospital Laboratory values 25 Biochemical parameters, blood values, chemistry, clinical chemistry parameters, hemoglobin, and platelet count + complete blood count, coagulation + hematology parameters, ABT, ALT, AST, liver function Viral load 24 SARS-Cov-2 negative conversion, COVID-19 PCR, COVID-19 serum antibody tests, COVID-19 viral load, microbiological cure Radiological change 20 Tayler’s scale, radiological findings, Computed Tomography findings, lung opacities, ground class opacities, patchy opacities Respiratory support 20 Ventilated, mechanical ventilation, ventilator-free days, respiratory function, respiratory improvement, extra-corporeal membraneoxygenation (ECMO) Abbreviations: ABT antibody titer,ALT alanine aminotransferase,AST aspartate aminotransferase,CRP C-reactive protein, ECMO extracorporeal membrane oxygenation, IL-6 interleukin 6, LDH lactate dehydrogenase, MODS multiorgan dysfunction score, NK natural killer, PCR polymerase chain reaction, SAPS simplified acute physiology score, SOFA sepsis-related organ failure assessment, TESAEs treatment-emergent serious adverse events.
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