Chapter 7 130 Figure 7: Workflow diagram of the review. The reviewers agreed directly in 89.2% of the cases. Three reviewers reviewed 10.4% of cases and four reviewers reviewed 1.5% of all cases (including a random sample review of 100 articles). TBP reviewed all 3,810 publications, followed by DGJC (N=1,847), SSA (N=1,843), and NK (N=631). The review was conducted in May and June 2022. The number of publications over time is depicted in Figure 8. We observe an increasing trend over time: from 12 therapeutic investigations in 2000 to 175 in 2021, (ρ= 0.96, p < 0.001).
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