Sarah Verhoeff

62 Chapter 3 SUPPLEMENTARY DATA Lasso model An exploratory WW-time Cox LASSO penalized regression approach considering the IMDC criteria, the number of affected organ sites, lung only disease, the sum of diameters of RECIST measurable lesions, [18F]FDG gm SUV max, and [ 89Zr]Zr-DFO-girentuximab gm SUV max selected lung only disease and [18F]FDG gm SUV max as optimal predictor set in our study population using 5-fold cross-validation. Under a 2500-fold bootstrap resampling approach, [18F]FDG gm SUVmax was selected in 99% of bootstraps, followed by lung only disease (69%) and IMDC (63%). [89Zr]Zr-DFO-girentuximab gm SUV max was selected in 40% of bootstrap samples. Figure S1. Flow diagram of patient enrolment. * Four patients were unfit for systemic treatment due to clinical deterioration resulting from rapid disease progression (n=3) or comorbidity and age (n=1). Three other patients did not wat systemic treatment.