74 Chapter 5 Quality control Quality control was performed by visually inspecting each tract for each subject (by BL, with 4 years of diffusion MRI experience). If tracts were segmented inadequately, the subject was excluded from this study. Two representative subjects, one patient with trigonocephaly and one control, are shown in Figure 1. Figure 1. Tractography of the representative patient and control. The tracts used in this study are depicted as colored tracts. These tracts include the anterior thalamic radiation (ATR), the inferior fronto-occipital fasciculus (IFO), uncinate fasciculus (UNC), cingulate gyrus part of the cingulum (CGC), the forceps minor (FMI), and the forceps major (FMA). The gray tracts were not used in this study and include the inferior longitudinal fasciculus (ILF), the hippocampal gyrus associated cingulum (CGH), and the corticospinal tract (CST). In each column, the left and superior views of the tracts are shown. Statistical analysis Statistical analysis was conducted using R Studio (version 4.03).22 Continuous data are presented as mean and standard deviation or as median and interquartile range (IQR), depending on whether the data are being distributed normally or not. Categorical data are presented as counts. Per tract histograms, boxplots and the Shapiro-Wilk test were used to confirm FA and MD were approximately normally distributed. Parametric statistics were used after establishing that the distribution of the data did not violate assumptions of normality. If a normal distribution was violated, several transformations
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