55 Cerebral Blood Flow | Trigonocephaly Frontal Lobe Perfusion By linear mixed model, Table 2 demonstrates that there was no significant difference in the mean cerebral blood flow of the frontal lobe between trigonocephaly patients (73 ml/100 g/ min) and control patients (70.5 ml/100 g/min, p = 0.65). Table 3 shows the mean perfusion for the superior, middle, and inferior frontal gyri. None of these three levels was significantly different between the patient and control groups. Table 2. Linear mixed model on the perfusion of the frontal lobe using the structural atlas (mL/100g/min). Trigonocephaly Control mean SE lower.ci upper.ci mean SE lower.ci upper.ci p-value Frontal lobe 73.0 2.97 67.0 78.9 70.5 4.45 61.6 79.4 0.65 Table 3. Linear mixed model on the three gyri of the frontal lobe using the Hammers Atlas (mL/100g/min). Trigonocephaly Control mean SE lower.ci upper.ci mean SE lower.ci upper.ci Superior frontal gyrus 70.9 2.90 65.1 76.7 68.2 4.34 59.5 76.9 Middle frontal gyrus 68.4 3.09 62.2 74.6 70.1 4.63 60.8 79.4 Inferior frontal gyrus 76.8 2.9 70.9 82.6 75.9 4.5 66.8 84.9 To account for physiological perfusion fluctuations, we chose the occipital lobe as a reference region for normalization. Both frontal/occipital cerebral blood flow ratios between patients and control subjects and the spatial coefficient of variance between patients and control subjects did not show a significant difference (p = 0.10 and p = 0.09, respectively). To demonstrate the range of values, the mean cerebral blood flow of the frontal lobe for each individual in our cohort is shown in Figure 1. Finally, sex had no significant effect on the frontal lobe perfusion in this cohort (p = 0.09). 3
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