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175 General Discussion REFERENCES 1. Doerga PN, Lequin MH, Dremmen MHG, et al. Cerebral blood flow in children with syndromic craniosynostosis: cohort arterial spin labeling studies. J Neurosurg Pediatr 2019:1-11 2. De Vis JB, Petersen ET, de Vries LS, et al. Regional changes in brain perfusion during brain maturation measured non-invasively with Arterial Spin Labeling MRI in neonates. Eur J Radiol 2013;82:538-543 3. Miranda MJ, Olofsson K, Sidaros K. Noninvasive measurements of regional cerebral perfusion in preterm and term neonates by magnetic resonance arterial spin labeling. Pediatr Res 2006;60:359-363 4. Rijken BF, Leemans A, Lucas Y, et al. Diffusion Tensor Imaging and Fiber Tractography in Children with Craniosynostosis Syndromes. AJNR Am J Neuroradiol 2015;36:1558-1564 5. van der Vlugt JJ, van der Meulen JJ, Creemers HE, et al. Cognitive and behavioral functioning in 82 patients with trigonocephaly. Plast Reconstr Surg 2012;130:885-893 6. Kelleher MO, Murray DJ, McGillivary A, et al. Behavioral, developmental, and educational problems in children with nonsyndromic trigonocephaly. J Neurosurg 2006;105:382-384 7. Cornelissen MJ, Loudon SE, van Doorn FE, et al. Very Low Prevalence of Intracranial Hypertension in Trigonocephaly. Plast Reconstr Surg 2017;139:97e-104e 8. Maltese G, Tarnow P, Wikberg E, et al. Intracranial volume before and after surgical treatment for isolated metopic synostosis. J Craniofac Surg 2014;25:262-266 9. Mocquard C, Aillet S, Riffaud L. Recent advances in trigonocephaly. Neurochirurgie 2019;65:246-251 10. Calpena E, Hervieu A, Kaserer T, et al. De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder. Am J Hum Genet 2019;104:709-720 11. Reijnders MRF, Miller KA, Alvi M, et al. De Novo and Inherited Loss-of-Function Variants in TLK2: Clinical and Genotype-Phenotype Evaluation of a Distinct Neurodevelopmental Disorder. Am J Hum Genet 2018;102:1195-1203 12. Jehee FS, Johnson D, Alonso LG, et al. Molecular screening for microdeletions at 9p22-p24 and 11q23-q24 in a large cohort of patients with trigonocephaly. Clin Genet 2005;67:503-510 13. Maliepaard M, Mathijssen IM, Oosterlaan J, et al. Intellectual, behavioral, and emotional functioning in children with syndromic craniosynostosis. Pediatrics 2014;133:e1608-1615 14. Kress W, Schropp C, Lieb G, et al. Saethre-Chotzen syndrome caused by TWIST 1 gene mutations: functional differentiation from Muenke coronal synostosis syndrome. Eur J Hum Genet 2006;14:39-48 15. Marucci DD, Dunaway DJ, Jones BM, et al. Raised intracranial pressure in Apert syndrome. Plast Reconstr Surg 2008;122:1162-1168 16. de Jong T, Bannink N, Bredero-Boelhouwer HH, et al. Long-term functional outcome in 167 patients with syndromic craniosynostosis; defining a syndrome-specific risk profile. J Plast Reconstr Aesthet Surg 2010;63:1635-1641 17. Woods RH, Ul-Haq E, Wilkie AO, et al. Reoperation for intracranial hypertension in TWIST1confirmed Saethre-Chotzen syndrome: a 15-year review. Plast Reconstr Surg 2009;123:18011810 18. Abu-Sittah GS, Jeelani O, Dunaway D, et al. Raised intracranial pressure in Crouzon syndrome: incidence, causes, and management. J Neurosurg Pediatr 2016;17:469-475 19. de Jong T, Rijken BF, Lequin MH, et al. Brain and ventricular volume in patients with syndromic and complex craniosynostosis. Childs Nerv Syst 2012;28:137-140 10

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