Hylke Salverda

82 Chapter 4 Figure 3D. Proportion of time spent within different SpO2 ranges including periods where no supplemental oxygen is administered. Dashed brown line: OxyGenie control, solid blue line: CLiO2 (D): Proportion of time in hyperoxia (SpO2 >98%) against postnatal age. Discussion In this study preterm infants receiving OxyGenie automated oxygen control during their stay in the NICU spent significantly more time within the target range than infants receiving CLiO2 automated oxygen control. This improvement was driven by less time spent in all hypoxic and hyperoxic ranges during supplemental oxygen therapy, and this improvement remained during all postnatal and postmenstrual ages. No differences were found in average inspired oxygen when supplemental oxygen is administered. The effect size reduced when episodes without supplemental oxygen were also included, but the superiority of OxyGenie was nevertheless still present. These results suggest that the conclusion from our randomised cross-over study14 – the choice of oxygen control device determines how successful SpO2 targeting will be – holds true for the entire stay in the NICU. This is the first study to describe the proportions of time within certain oxygen saturation ranges during different phases of a preterm infants’ stay in the NICU. In only one study automated oxygen control during the entire stay was researched. D