75 4 Comparison of two AOCs in oxygen targeting in preterm infants during admission Table 1. Baseline characteristics of recordings >72 hours while supplemental oxygen administered Patient characteristics n = 186 Oxygenie n=75 CLiO2 n=111 p value* Gestational age in weeks days, median [IQR] 270 [253 – 275) 266 [254 – 280] n.s. Birth weight in grams, mean (SD) 934 (239) 901 (215) n.s. Small for gestational age, n (%) 8 (10.7) 8 (7.2) n.s. Males, n (%) 42 (56.0) 52 (46.8) n.s. Antenatal corticosteroids, n (%) 66 (88.0) 94 (84.7) n.s. Caesarean delivery, n (%) 36 (48.0) 63 (56.8) n.s. Multiple pregnancy, n (%) 26 (34.7) 42 (37.8) n.s. Recording length in hours, median [IQR] 336 [186 – 598] 398 [165 – 693] n.s. FiO2, fraction of inspired oxygen; CPAP, continuous positive airway pressure; *Mann-Whitney U test, independent T-test or chi-square test as appropriate Baseline characteristics for the secondary analysis population also did not differ between epochs (Table 2). Median recording length of vital parameters was 490 hours [IQR 350 – 747] in the OxyGenie epoch and 520 [IQR 321 – 751] in the CLiO2 epoch (p = ns). Table 2. Baseline characteristics of all recordings >72 hours, including room air episodes Patient characteristics N = 415 Oxygenie N=146 CLiO2 N=269 p value* Gestational age in weeks days, median [IQR] 280 [266 – 290] 281 [266 – 286] n.s. Birth weight in grams, mean (SD) 1038 (270) 1050 (250) n.s. Small for gestational age, n (%) 16 (11.0) 21 (7.8) n.s. Males, n (%) 137 (50.9) 80 (54.8) n.s. Antenatal corticosteroids, n (%) 133 (91.1) 236 (87.7) n.s. Caesarean delivery, n (%) 74 (50.7) 148 (55.0) n.s. Multiple pregnancy, n (%) 55 (37.7) 93 (34.6) n.s. Recording length in hours, median [IQR] 490 [350 – 747] 520 [321 – 751] n.s. FiO2, fraction of inspired oxygen; CPAP, continuous positive airway pressure; *Mann-Whitney U test, independent T-test or chi-square test as appropriate

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