43 2 Automated oxygen control in preterm infants, how does it work and what to expect Conclusion In summary, the field of automated oxygen control is evolving and the technology unquestionably holds promise. Automated oxygen control increases time spent within SpO2 target range, decreases hyperoxia and severe hypoxia and is likely to reduce workload. Several solutions are commercially available, each of which has its own strategy. However, there are many unknown factors in the response of premature infants to each algorithm. Studies using the algorithms are heterogeneous and meaningful comparative data are lacking. Evidence is needed on how different controllers perform under certain circumstances, so clinicians know what to expect. A head-to-head comparison of algorithms is required under uniform conditions so that clinicians can fully understand how to apply this technology as part of the vital respiratory care provided to preterm infants.