34 Chapter 2 Table 1: Studies on automated oxygen control Oxygen control algorithm Author (year) Study duration SpO2 TR Gestational age in weeks Age at entry study n CLACslow Urschitz (2004)17 3x90 min 87%-96% 25.5 (24-33) 20.5 days (4 - 78) 12 Hallenberger (2014)27 2x24 hrs 90%-95% 80%-92% 83%-93% 85%-94% 26.4 (23.0-35.3) 29.9 weeks (26.0 – 35.6) 34 CLACfast Schwarz (2019)26 3x8 hrs 90%-95% 85%-93% 85%-96% 26.4 (24.0-32.7) 24 days ± 10 19 CLiO2 Claure (2001)18 2x2 hrs 88%-96% 25 ±1.6 26 days ± 11 14 Claure (2009)28 2x4 hrs 88%-95% 24.9 ±1.4 33 days ± 15 16 Claure (2011)29 2x24 hrs 87%-93% 25 (24-27) 27 days [17-36] 32 Waitz (2015)30 2x24 hrs 88%-96% 25 (23-28) 34 days [19-75] 15 Van Kaam (2015) 31 2x24 hrs 91%-95% (1) 89%-93% (2) 26 (25-28) 18 days [10-29] 80 Lal (2015)32 2x12 hrs 90%-95% 25 (24-27) 16 days [9-27] 27 Van Zanten (2017)33 3-28 days 90%-95% 27+6 (26+3-28+4) 27+3 (26+0-28+2) n/a 42 PRICO ‡ n/a n/a n/a n/a n/a n/a SPO2C Gajdos (2018)34 2x24 hrs 88%-96% 25.3 (23-26) 31.5 days [12 – 62] 12 IntellO2 Reynolds (2018)35 2x24 hrs 93% (A) 90%-95% (M) 26 (24-27) 29 days [18-53] 30 VDL1.0 Plottier (2017)36 3x4 hrs 91%-95% (A) 90%-94% (M) 27.5 [26-30] 8 days [1.8-34] 20 Mean ±SD or median[IQR] or (range). TR, target range; n/a, not applicable/available; RMC, routine manual control; NCPAP, nasal continuous airway pressure; MV, mechanical ventilation. P-values are two sides unless indicated otherwise. *one sided superiority test; †one sided non-inferiority test. ‡For PRICO no clinical data are available to date.
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