Hylke Salverda

Financial support for the printing of this thesis was kindly provided by: Universitaire Bibliotheken Leiden Department of Paediatrics of the Leiden University Medical Center SLE Limited Cover by: Ridderprint, www.ridderprint.nl Printed by: Ridderprint, www.ridderprint.nl Layout by: Hylke Salverda ISBN: 978-94-6458-500-1 E-ISBN: 978-94-6458-501-8 The studies in this thesis were financially supported by an unrestricted research grant from SLE Limited; they had no role in study design nor in the collection, analysis, and interpretation of data, writing of the reports and decision to submit this manuscript or the papers for publication. Copyright © 2022 by Hylke H. Salverda All rights reserved. No part of this book may be reproduced, stored in a retrieval system of any system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, included a complete or partial transcription, without the prior written permission of the author.