142 Chapter 8 and Min22 to retain the matching of the data. Statistical analyses were performed by IBM SPSS Statistics for Mac, version 25 (IBM, Armonk, New York, USA) and R 4.1.0 (R Core Team (2021). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. https://www.R-project.org/). Two-tailed P-values of <0.05 were considered statistically significant. Results 158 infants were born between November 2018 - March 2020 of which 121 were eligible for inclusion in the OxyGenie cohort. These were then matched with infants born in the period October 2015 - April 2018 to form the control, or CLiO2, cohort (n=121) (table 1). In the OxyGenie cohort 51 infants were male (42%), there was a median gestational age at birth of 28 weeks and 3 days [26 weeks and 3.5 days – 29 weeks] and a birth weight of 1034 (266) grams. In the CLiO2 cohort there were 55 males (46%), there was a median gestational age of 27 weeks and 5 days [26 weeks and 5 days – 28 weeks and 3 days] and a birth weight of 1022 (242) grams. As our centre is a referral centre for foetal treatment we have a relatively large number of multiple pregnancy (45 in the OxyGenie cohort vs. 41 in the CLiO2 cohort). There were no statistically significant differences between groups in beforementioned patient characteristics. Table 1. Patient characteristics Patient characteristics n = 242 OxyGenie n = 121 CLiO2 n = 121 p value* Gestational age in weeksdays, median [IQR] 283 [263.5 – 29] 275 [265 – 283] 0.09 Birth weight in grams, mean (SD) 1034 (266) 1022 (242) 0.60 Small for gestational age, n (%) 12 (10.1) 8 (6.6) 0.30 Males, n (%) 51 (42.1) 55 (45.5) 0.60 Antenatal corticosteroids, n (%) 107 (92.2) 106 (89.1) 0.50 Caesarean delivery, n (%) 64 (52.9) 66 (54.5) 0.90 Multiple pregnancy, n (%) 45 (37.2) 41 (33.9) 0.70 of which monochorionic twins, n (%) 22 (48.9) 26 (63.4) Perinatal asphyxia, n (%) 5 (4.1) 1 (0.8) 0.22 Apgar score at 5 minutes, median (range) 8 (0-10) 8 (2-10) 0.79 *Statistical analysis with related-samples Wilcoxon signed rank test or related-samples McNemar test as appropriate.
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