110 Chapter 6 Table 1. Patient characteristics Patient characteristics N = 588 Pre-AOC N = 293 Post-AOC N = 295 p value* Gestational age in weeks, mean (SD) 27.8 (1.5) 27.6 (1.6) 0.12 Birth weight in grams, mean (SD) 1038 (292) 1035 (260) 0.88 Small for gestational age, n (%) 32 (10.9) 21 (7.2) 0.15 Males, n (%) 165 (56.3) 155 (52.5) 0.36 Antenatal corticosteroids, n (%) 250 (86.2) 255 (87.3) 0.69 Caesarean delivery, n (%) 145 (49.5) 157 (53.2) 0.37 Multiple pregnancy, n (%) 115 (39.2) 99 (33.5) 0.45 of which monochorionic twins, n (%) 71 (61.7) 64 (64.6) Perinatal asphyxia, n (%) 4 (1.4) 8 (2.7) 0.25 Apgar score at 5 minutes, median (range) 8 (2-10) 8 (1-10) 0.87 *Statistical analysis with independent T-test, chi-square, or nonparametric MannWhitney U test as appropriate Clinical outcomes Mortality up until one month beyond full term corrected age was similar between groups (pre vs. post implementation: 30 (10.2%) vs 32 (10.8%); p=0.81; table 2). There were no differences in morbidities between the groups, except that the incidence of culture proven sepsis in the post-implementation group was higher (96 (32.8%) vs 121 (41.0%); p = 0.038). The length of stay in the NICU was not different between groups (32.9 ±15.4 vs 35.4 ±27.0; p = 0.27).

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