61 Bronchopulmonary dysplasia, IGF-I & nutrition 3 Supplemental material Methods Definitions of diseases included as clinical data Necrotizing enterocolitis was defined according to the modified Bell criteria (Walsh 1986). I. Stage1ASuspectedNEC basedontemperatureinstability, apnea,bradycardy, or lethargy combined with gastric retention, abdominal distention, emesis, or heme-positive stool and normal or mild intestinal dilation, or mild ileus on radiography. II. Stage 1B Suspected NEC based on temperature instability, apnea, bradycardy, or lethargy combined with grossly bloody stool and normal or mild intestinal dilation, or mild ileus on radiography. III. Stage 2A definite NEC (mildly ill) based on temperature instability, apnea, bradycardy, or lethargy combined with grossly bloody stool and absent bowel sounds with or without abdominal tenderness and Intestinal dilation, ileus, or pneumatosis intestinalis on radiography. IV. Stage 2B definite NEC (moderately ill) based on temperature instability, apnea, bradycardy, or lethargy, as well as mild metabolic acidosis and thrombocytopenia, combined with grossly bloody stool and absent bowel sounds, definite tenderness, with or without abdominal cellulitis or right lower quadrant mass and Intestinal dilation, ileus, pneumatosis intestinalis and ascites on radiography. V. Stage 3A advanced NEC (severely ill, intact bowel) based on temperature instability, severe apnea, bradycardia, hypotension, lethargy, respiratory and metabolic acidosis, disseminated intravascular coagulation, and neutropenia combined with grossly bloody stool and absent bowel sounds, signs of peritonitis, marked tenderness, and abdominal distention, with or without abdominal cellulitis or right lower quadrant mass and Intestinal dilation, ileus, pneumatosis intestinalis and ascites on radiography. VI. Stage 3B advanced NEC (severely ill, perforated bowel) based on temperature instability, severe apnea, bradycardia, hypotension, lethargy, respiratory and metabolic acidosis, disseminated intravascular coagulation, and neutropenia combined with grossly bloody stool and absent bowel sounds, signs of peritonitis, marked tenderness, and abdominal distention, with or without abdominal cellulitis or right lower quadrant mass and Intestinal dilation, ileus, pneumatosis intestinalis, ascites and pneumoperitoneum on radiography. Walsh MC, Kliegman RM. Necrotizing enterocolitis: treatment based on staging criteria. Pediatr Clin North Am 1986;33(1):179-201. doi: 10.1016/s0031-3955(16)34975-6 [published Online First: 1986/02/01]
RkJQdWJsaXNoZXIy MTk4NDMw