I 406

Aernoud Fiolet

Chapter 1 General introduction and thesis outline 11
PART I: The role of crystal-induced inflammation in atherosclerosis 49
Chapter 2 Viewing Atherosclerosis through a Crystal Lens: How the Evolving Structure of Cholesterol Crystals in Atherosclerotic Plaque Alters its Stability 51
Chapter 3 Colchicine in Stable Coronary Artery Disease 73
PART II: Efficacy and safety of colchicine in coronary disease 91
Chapter 4 The effect of low-dose colchicine in patients with stable coronary artery disease: The LoDoCo2 trial rationale, design, and baseline characteristics 93
Chapter 5 Colchicine in Patients with Chronic Coronary Disease 117
Chapter 6 Reply. Colchicine in Patients with Chronic Coronary Disease 161
Chapter 7 The efficacy and safety of low-dose colchicine in patients with coronary disease: a systematic review and meta-analysis of randomised trials 173
Chapter 8 Colchicine in chronic coronary disease in relation to history of acute coronary syndrome 215
PART III: Insights in mechanism and tolerance 231
Chapter 9 Short-term effect of low-dose col chicine on inflammatory biomarkers, lipids, blood count and renal function in chronic coronary artery disease and elevated high-sensitivity C-reactive protein 233
Chapter 10 Colchicine Attenuates Inflammation Beyond the Inflammasome in Chronic Coronary Artery Disease. A LoDoCo2 Proteomic Substudy 257
Chapter 11 Colchicine reduces extracellular vesicle NLRP3 inflammasome protein levels in vitro and in vivo in chronic coronary disease: a LoDoCo2 substudy 267
Chapter 12 Predictors of early intolerance to low-dose colchicine in patients with coronary disease 291
PART IV: Improving pragmatic trial conduct 311
Chapter 13 Text-mining in electronic healthcare records can be used as efficient tool for screening and data collection in cardiovascular trials: a multicenter validation study 313
Chapter 14 Accuracy of using routinely collected electronic healthcare data to identify major cardiovascular endpoints in randomized controlled trials: a multicenter validation study 337
PART V: General discussion and summary 357
Chapter 15 Clinical implications and future perspectives 359
Chapter 16 Summary 381
Appendices 389
Summary in Dutch 391
List of publications 399

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