196 Chapter 7 Supplementary Table S1B: Individual end points and definitions End point and definition Source Myocardial infarction LoDoCo2 Defined by the ACC/AHA/ESC 3rd third universal definition of (acute) myocardial infarction 1 COPS Detection of a rise and/or fall of cardiac troponin with at least one value above the 99th percentile upper reference limit and with at least one of the following: Symptoms of ischaemia; New or presumed new ST-segment-T wave (ST-T) changes or new left bundle branch block (LBBB); Development of pathological Q waves in the ECG; Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality; Identification of an intracoronary thrombus by angiography or autopsy 2 COLCOT NA 3 LoDoCo Acute ischemic chest pain associated with a rise in serum troponin above the upper limit of normal Personal communication4 Stroke LoDoCo2 Ischemic and haemorrhagic stroke Personal communication1 COPS Ischemic and haemorrhagic stroke Personal communication2 COLCOT Ischemic and haemorrhagic stroke 3,5 LoDoCo Ischemic and haemorrhagic stroke Personal communication4 Ischemic stroke LoDoCo2 Ischemic stroke; requires ethological, imaging, or other objective evidence of acute, focal cerebral, spinal, or retinal ischemic injury in a defined vascular distribution; or clinical evidence of acute, focal cerebral spinal cord, or retinal ischemic injury based on symptoms persisting >24 hours or until death, and other aetiologies excluded. Ischemic stroke includes haemorrhagic infarction but not intracerebral or subarachnoid haemorrhage. Includes atherosclerotic, cardio-embolic and lacunar stroke. 1 COPS Non-cardioembolic ischaemic stroke; computed tomography (CT)- or magnetic resonance imaging (MRI)-proven ischaemic stroke judged by the treating neurologist as not being due to atrial fibrillation or intracranial haemorrhage 2 COLCOT NA 5 LoDoCo Computed tomography—or magnetic resonance imaging—proven ischemic stroke judged by the treating neurologist as not being due to intracranial haemorrhage Personal communication4 NA: not available
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