Chapter 5 86 Table 4. Results of univariable and multivariable analyses Overall survival HR CI Age, years ≤65 1.00 - >65 1.43 1.10-1.86 Gender Female 1.00 - Male 1.06 0.81-1.39 ASA 1-2 1.00 - 3-4 1.08 0.74-1.60 T-stage primary T0/T1/T2 1.00 - T3/T4 1.43 1.01-2.02 N-stage primary N0 1.00 - N1/N2 1.58 1.20-2.08 Neoadjuvant radiotherapy primary No 1.00 - Short-course radiotherapy 1.29 0.94-1.76 Full-course (chemo)radiotherapy 1.42 1.03-1.96 Type of surgery TEM 1.00 - Rectosigmoid/LAR 0.95 0.48-1.86 Abdominoperineal resection 1.17 0.58-2.35 Adjuvant therapy primary None 1.00 - Chemotherapy 1.03 0.73-1.45 Number of recurrences 1 1.00 - 2-3 0.99 0.68-1.44 Induction chemotherapy No 1.00 - Yes 0.99 0.73-1.35 Neoadjuvant radiotherapy LRRC None 1.00 - Short-course radiotherapy 0.93 0.22-3.99 Full-course (chemo)radiotherapy 0.46 0.27-0.76 (Chemo)reirradiation 0.63 0.39-1.02 Type of surgery LRRC Low anterior resection 1.00 - Abdominoperineal resection 1.40 0.22-3.99 Multivisceral resection 1.41 0.27-0.76 Nonvisceral resection 1.34 0.39-1.02 Intraoperative radiotherapy None 1.00 - Yes 0.83 0.59-1.18 Metastases No 1.00 - History 0.89 0.58-1.36 Synchronous 1.43 0.98-2.11 Number of metastases Single 1.00 - Multiple 1.19 0.68-2.07 Resection margin R0 1.00 - R1/R2 2.14 1.61-2.85
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