Chapter 5 76 Theend-pointswereoverall survival (OS: timebetween thedateof LRRCsurgeryand the date of death or last follow-up), local recurrence-free survival (LRFS: the time between the date of LRRC surgery and the date of histologically or radiologically proven local re-recurrence or last follow-up), and metastasis-free survival (MFS: the time between the date of LRRC surgery and the date of histologically or radiologically proven distant metastases or last follow-up). TheOS, LRFS andMFSwere estimated using the Kaplan-Meiermethod, and differences were assessed using the log rank test. For multivariable analyses, the Cox regression methodwas applied using all variables with a P <0.100 in the univariable analyses. Twosided P-values of <0.05were considered statistically significant. Statistical analysiswas performed using IBM SPSS® version 23 for Windows® (IBM, Armonk, NY, USA).
RkJQdWJsaXNoZXIy MTk4NDMw