Improved outcomes for responders to induction chemotherapy 43 CHAPTER 3 Local recurrence Disease-free survival Overall survival HR CI P-value HR CI P-value HR CI P-value 0.989 0.957-1.021 0.941 0.997 0.970-1.026 0.856 1.013 0.974-1.053 0.514 1.00 1.00 1.00 1.378 0.705-2.693 0.349 1.208 0.677-2.157 0.522 0.904 0.437-1.870 0.785 1.00 1.00 1.00 0.835 0.299-2.329 0.730 0.575 0.209-1.585 0.285 1.081 0.328-3.558 0.898 1.00 1.00 1.00 1.459 0.520-4.098 1.072 0.484-2.375 1.193 0.419-3.398 1.770 0.531-5.903 0.650 1.049 0.389-2.827 0.985 0.767 0.170-3.466 0.746 1.00 1.00 1.00 0.726 0.361-1.461 0.842 0.459-1.542 0.744 0.332-1.668 1.827 0.928-3.607 0.034 1.536 0.839-2.810 0.150 1.311 0.613-3.022 0.366 1.00 1.00 1.00 1.539 0.637-3.718 1.765 0.834-3.738 1.216 0.466-3.177 2.558 1.162-5.629 0.043 2.319 1.165-4.613 0.055 2.061 0.890-4.771 0.171 1.00 1.00 1.00 1.334 0.511-3.484 1.857 0.721-4.779 0.694 0.248-1.938 1.311 0.488-3.521 0.837 2.113 0.811-5.501 0.309 1.519 0.555-4.1607 0.093 1.00 1.00 1.00 0.840 0.408-1.731 0.637 0.916 0.478-1.757 0.792 1.049 0.438-2.516 0.914 1.00 1.00 1.00 0.952 0.376-2.411 0.917 0.729 0.314-1.692 0.462 1.302 0.501-3.383 0.588 1.00 1.00 1.00 1.141 0.534-2.441 0.734 1.325 0.690-2.534 0.398 0.610 0.185-2.010 0.416 1.00 1.00 1.00 1.877 0.744-4.733 0.182 1.466 0.698-3.076 0.312 1.533 0.595-3.946 0.376 1.00 1.00 1.00 1.702 0.421-6.889 1.679 0.482-5.846 0.533 0.058-4.900 1.451 0.508-4.143 1.662 0.651-4.244 1.228 0.417-3.617 1.404 0.460-4.282 0.890 1.536 0.567-4.158 0.763 1.301 0.406-4.168 0.833 1.00 1.00 1.00 1.077 0.456-2.544 0.866 1.277 0.581-2.808 0.542 0.682 0.283-1.645 0.682 1.00 1.00 1.00 3.595 2.042-6.330 <0.001 2.541 1.524-4.236 <0.001 3.271 1.699-6.298 <0.001 1.00 1.00 1.00 2.893 1.112-7.526 2.278 1.053-4.927 6.236 1.461-26.624 6.754 2.467-18.494 <0.001 4.296 1.869-9.876 0.002 9.501 2.124-42.497 0.012
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